Antihypertensive drugs in clinical development.

CLINICAL PROGRESS Clinical Evaluation of Antihypertensive Drugs

T HE evaluation of antihypertensive drugs has become a big business. Hundreds of people who work in some aspect of clinical investigation spend at least part of their time in this process. Their observations determine the expenditure, first by the drug companies and then by the public, of some millions of dollars a year. Even the law recognizes the fact that no accumulation of pharmacology, how...

Antihypertensive Drugs

Hypertension is one of the most serious concerns of modern medical practice. It is estimated that in the United States, as many as 60 million people are hypertensive or are being treated with antihypertensive drugs. Among the growing population of elderly Americans, some 15 million have high blood pressure. The level of blood pressure in itself is not a chief concern, since individuals with hig...

THE EFFECT OF ANTIHYPERTENSIVE DRUGS IN THE SUPPRESSION OF ATHEROSCLEROSIS

The present investigation was undertaken to evaluate the effect of antihypertensive drugs on aortic atherogenesis in hypercholesterolemic rabbits. In enalapril and nifedipine treated rabbits aortic atherosclerotic plaque involvement was significantly decreased (p<0. Oland p<O. 05, respectively) as compared to the control group. However, in hydrochlorothiazide treated rabbits aortic atheroge...

Antihypertensive drugs in pregnancy.

A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice

Persistence on treatment affects the efficacy of antihypertensive treatment. We prospectively investigated the persistence on therapy and the extent of blood pressure (BP) control in 347 hypertensive patients (age 59.4 +/- 6 years) randomly allocated to a first-line treatment with: angiotensin-converting enzyme (ACE) inhibitors, calcium-channel blockers (CCBs), beta-blockers, angiotensin-II rec...